Fig 2: Receiver-operating characteristic (ROC) analyses for predicting poor outcomes at six months after cardiac arrest: immediately after return of spontaneous circulation (A), 24 h after return of spontaneous circulation (B), and 48 h after return of spontaneous circulation (C). One asterisk (*) denotes a significantly different area under the ROC curve (AUROC) compared to the AUROC of S–100 B (DeLong's test, p < 0.05). Two asterisks (**) denote a significantly different AUROC compared to the AUROCs of both S–100 B and neuron-specific enolase (NSE) (DeLong's test, p < 0.05). Three asterisks (***) denote a significantly different AUROC compared to the AUROC of NSE alone (DeLong's test, p < 0.05). NSE: neuron-specific enolase; SBDP145: spectrin breakdown product 145 kDa; Nf-H: neurofilament heavy chain; AUROC: area under the receiver-operating characteristic curve.